Potassium Hydroxide → HCID 67674953, compound

HRID 1957028Notes

Reaction equation

HRID 1957028 reaction equation
C[O:2][C:3](=[O:30])[C@:4]([CH3:29])([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:28]=[CH:27][S:26][CH:25]=2)=[CH:20][CH:19]=1)[N:5]([C:7](=[O:16])[C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=1)[CH3:6].[OH-].[K+]>C(O)C.O>[CH3:14][C:12]1[CH:13]=[C:8]([CH:9]=[C:10]([CH3:15])[CH:11]=1)[C:7]([N:5]([CH3:6])[C@:4]([CH3:29])([C:3]([OH:30])=[O:2])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:28]=[CH:27][S:26][CH:25]=2)=[CH:20][CH:19]=1)=[O:16]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 67674844HCID 67674844, compound

Product 1

HCID 67674953HCID 67674953, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A stirred solution of N-(3,5-dimethylbenzoyl)-N-methyl-2-methyl-3-[4-(3-thienyl)phenyl]alanine methyl ester (100 mg, 0.245 mmol) and potassium hydroxide (40 mg, 0.72 mmol) in ethanol (5 ml) is refluxed overnight. The mixture is diluted with water and washed with ether. The aqueous layer is washed with brine, dried over magnesium sulfate, and concentrated in vacuo to give the corresponding crude N-(3,5-dimethylbenzoyl)-N-methyl-2-methyl-3-[4-(3-thienyl)phenyl]alanine

Workup

  1. washwashed with ether
  2. washThe aqueous layer is washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-bfa2d77f57f246d6af05aeba26ee4adb
Source dataset
uspto-grants-1998_07
Patent number
US05780498

Reaction notes

Loading…