Hydrochloric Acid → HCID 4241808, compound

HRID 1957087Notes

Reaction equation

HRID 1957087 reaction equation
C([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:16]=[CH:15][C:14](=[O:17])[CH:13]=[CH:12]2)=[CH:7][CH:6]=1)C.[OH-].[K+].Cl>CO>[O:17]=[C:14]1[CH:13]=[CH:12][N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:18])=[O:3])=[CH:6][CH:7]=2)[CH:16]=[CH:15]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 21819194HCID 21819194, compound

Product 1

HCID 4241808HCID 4241808, compoundYield 102.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-(4-oxo-4H-pyridin-1-yl)benzoic acid ethyl ester (10.0 gm, 41.1 mmol), potassium hydroxide (6.92 g, 123 mmol) and methanol (250 ml) was stirred overnight at room temperature. The mixture was acidified by dropwise addition of concentrated hydrochloric acid and the precipitate was collected by suction filtration to give the product as a white powder (9.08 g).

Workup

  1. filtrationthe precipitate was collected by suction filtration

Sources & evidence

ORD record
ord-1a3dd09fceed4ba6a4987fbf665a4fe8
Source dataset
uspto-grants-1998_07
Patent number
US05783114

Reaction notes

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