Methyl iodide → HCID 19600930, compound

HRID 1957183Notes

Reaction equation

HRID 1957183 reaction equation
[CH3:1][C:2]1([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH2:17][CH3:18])[CH:9]=2)[O:6][C:5](=[O:7])[NH:4][CH2:3]1.[OH-].[K+].[CH3:21]I>O1CCCC1>[CH2:17]([O:16][C:10]1[CH:9]=[C:8]([C:2]2([CH3:1])[O:6][C:5](=[O:7])[N:4]([CH3:21])[CH2:3]2)[CH:13]=[CH:12][C:11]=1[O:14][CH3:15])[CH3:18]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 19358526HCID 19358526, compound

Product 1

HCID 19600930HCID 19600930, compoundYield 37.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

500 mg (2.0 mmol) of 5-methyl-5-(3-ethoxy-4-methoxyphenyl)-2-oxazolidinone, 125 mg (2.22 mmol) of potassium hydroxide, and 0.167 ml (2.38 mmol) of methyl iodide were stirred in 4 ml of tetrahydrofuran for 4 hours at room temperature. The process was continued analogously to Example 8, thus obtaining 201 mg of 5-(3-ethoxy-4-methoxyphenyl)-3,5-dimethyl-2-oxazolidinone as an oil.

Sources & evidence

ORD record
ord-77e1f2a518094a75ae4cd58434ed88c6
Source dataset
uspto-grants-1998_07
Patent number
US05783591

Reaction notes

Loading…