HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl bromide → 3-Chloro-2-(4-chloro-2-fluoro-5-propargyloxyphenyl)-5-trifluoromethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | 2-Chloro-5-(3-chloro-5-trifluoromethylpyrid-2-yl)-4-fluorophenol | HCID 11823568 | — |
| Reactant | 3-Chloro-2-(4-chloro-3-propargyloxyphenyl)-5-trifluoromethylpyridine | HCID 19068758 | — |
| Product | 3-Chloro-2-(4-chloro-2-fluoro-5-propargyloxyphenyl)-5-trifluoromethylpyridine | HCID 11451352 | 67% |
Reaction Steps
In a preparation similar to that described above for 3-chloro-2-(4-chloro-3-propargyloxyphenyl)-5-trifluoromethylpyridine, reaction of 1.4 g (4.5 mmol) of 3-chloro-2-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-trifluoromethylpyridine and 0.6 g (5 mmol) of propargyl bromide resulted in 1.1 g of colorless crystals. Yield: 67%; melting point: 97°-98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05783522 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-e098c80d18ca491ba9f935c04f4ec9e6 |
| Source note | uspto-grants-1998_07 |