反应详情

温度

80 °C

3.0 g (9.3 mmol) of 3-chloro-2-(4-chloro-3-methoxyphenyl)-5-trifluoromethylpyridine and 0.7 g (10 mmol) of sodium thiomethoxide in a mixture of 50 ml of methanol and 20 ml of dimethylformamide were stirred at 80° C. for 7 h and then at 23° C. for 72 h. The mixture was then poured into 500 ml of ice-water, which was then extracted three times with 150 ml of tert-butyl methyl ether each time. The combined organic phases were washed twice with 100 ml of water each time, dried over sodium sulfate and concentrated.

1. waitat 23° C. for 72 h
2. extractionwas then extracted three times with 150 ml of tert-butyl methyl ether each time
3. washThe combined organic phases were washed twice with 100 ml of water each time
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated