Ethyl 2-bromopropionate → HCID 19068739, compound

HRID 1957253Notes

Reaction equation

HRID 1957253 reaction equation
ClC1C(C2C=CC(Cl)=C(SCC#C)C=2)=NC=C(C(F)(F)F)C=1.[Cl:23][C:24]1[C:25]([C:34]2[CH:39]=[CH:38][C:37]([Cl:40])=[C:36]([SH:41])[CH:35]=2)=[N:26][CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1.Br[CH:43]([CH3:49])[C:44]([O:46][CH2:47][CH3:48])=[O:45]>COC(C)(C)C>[Cl:23][C:24]1[C:25]([C:34]2[CH:39]=[CH:38][C:37]([Cl:40])=[C:36]([S:41][CH:43]([C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH3:49])[CH:35]=2)=[N:26][CH:27]=[C:28]([C:30]([F:32])([F:33])[F:31])[CH:29]=1

Participants

5

Reactant 3

HCID 79040Ethyl 2-bromopropionateHCID 19068744HCID 19068744, compoundHCID 19068747HCID 19068747, compound

Product 1

HCID 19068739HCID 19068739, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

In a preparation similar to that described above for 3-chloro-2-[4-chloro-3-(2-propynylthio)phenyl]-5-trifluoromethylpyridine, reaction of 2.0 g of 3-chloro-2-(4-chloro-3-mercaptophenyl)-5-trifluoromethylpyridine with 1.11 g of ethyl 2-bromopropionate and extraction of the product with tert-butyl methyl ether afforded 2.4 g (92%) of a colorless oil.

Workup

  1. customIn a preparation similar to

Sources & evidence

ORD record
ord-21df867092e6400da1ff442223bfae3d
Source dataset
uspto-grants-1998_07
Patent number
US05783522

Reaction notes

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