Sodium ethoxide → HCID 19068788, compound

HRID 1957272Notes

Reaction equation

HRID 1957272 reaction equation
ClC1C(C2C=CC(Cl)=C(NS(C)(=O)=O)C=2)=NC=C(C(F)(F)F)C=1.[Cl:24][C:25]1[C:26]([C:35]2[CH:40]=[CH:39][C:38]([C:41]#[N:42])=[C:37]([N:43](S(CC)(=O)=O)[S:44]([CH2:47][CH3:48])(=[O:46])=[O:45])[CH:36]=2)=[N:27][CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1.[O-]CC.[Na+]>C(O)C>[Cl:24][C:25]1[C:26]([C:35]2[CH:40]=[CH:39][C:38]([C:41]#[N:42])=[C:37]([NH:43][S:44]([CH2:47][CH3:48])(=[O:45])=[O:46])[CH:36]=2)=[N:27][CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1

Participants

5

Reactant 3

HCID 2723922Sodium ethoxideHCID 15766881HCID 15766881, compoundHCID 19068774HCID 19068774, compound

Product 1

HCID 19068788HCID 19068788, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a preparation similar to that described above for 3-chloro-2-(4-chloro-3-methylsulfonylaminophenyl)-5-trifluoromethylpyridine, use of 4.2 g of 3-chloro-2-[4-cyano-3-bis(ethylsulfonyl)aminophenyl]-5-trifluoromethylpyridine, about 100 mg of sodium ethoxide and 100 ml of ethanol resulted in 2.0 g (59%) of colorless crystals;

Workup

  1. customIn a preparation similar to

Sources & evidence

ORD record
ord-f69b31ef637d45feb17e96fcf931db8c
Source dataset
uspto-grants-1998_07
Patent number
US05783522

Reaction notes

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