Methylamine → N-Methyl-2-phenylacetamide

HRID 1957275Notes

Reaction equation

HRID 1957275 reaction equation
[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][NH2:12]>C1C=CC=CC=1>[CH3:11][NH:12][C:8](=[O:9])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 7679Phenylacetyl chloride

Product 1

HCID 81274N-Methyl-2-phenylacetamide

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

Dissolved 15 g(0.1 mol) of phenylacetyl chloride in 100 ml of benzene. While stirring on a magnetic stirrer, introduced methylamine into the benzene solution at 20°-30° C. Followed the procedure of compound 3-1 for the purification of the product to yield N-methyl phenylacetamide as light yellowish crystal. Yield, 12 g (80%).

Workup

  1. customFollowed the procedure of compound 3-1 for the purification of the product

Sources & evidence

ORD record
ord-78eab7f62f12455e952eaf02f1cbcc37
Source dataset
uspto-grants-1998_07
Patent number
US05783605

Reaction notes

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