Triethylamine → HCID 19069747, compound

HRID 1957318Notes

Reaction equation

HRID 1957318 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]([OH:7])=O)[CH3:2].[CH2:8]([N:12]=[C:13]=[S:14])[CH:9]([CH3:11])[CH3:10].C(N(CC)CC)C>C(Cl)Cl>[CH2:1]([N:3]1[CH2:4][C:5](=[O:7])[N:12]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:13]1=[S:14])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 68960Isobutyl isothiocyanateHCID 316542N-Ethylglycine

Product 1

HCID 19069747HCID 19069747, compoundYield 23.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by the procedure described in Example 4 using 9.2 g of N-ethyl glycine, 5.7 g of isobutyl-isothiocyanate, 10.1 g of triethylamine, and 150 mL of methylene chloride. Purification was achieved by flash chromatography on silica gel (methylene chloride). Title compound (2.3 g) was obtained as an oil. Anal. Calcd. for. C9 H16N2O S: C, 53.97; H, 8.05; N, 13.99. Found: C, 54.01; H, 8.21; N, 14.00. Mass spectrum (EI, M.+) m/z 200.

Workup

  1. customThe title compound was prepared by the procedure
  2. customPurification

Sources & evidence

ORD record
ord-ee8cf3a36cbb4ac18f4716a919cbc70a
Source dataset
uspto-grants-1998_07
Patent number
US05783707

Reaction notes

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