Piperidine → Piperidine-1-sulfonyl chloride

HRID 1957391Notes

Reaction equation

HRID 1957391 reaction equation
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([S:1]([Cl:5])(=[O:3])=[O:2])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 24648Sulfuryl chloride

Product 1

HCID 11298344Piperidine-1-sulfonyl chloride

Procedure

A solution of 4 g of sulfuryl chloride in acetronitrile was treated dropwise with 861 mg of piperidine at ambient temperature under an atmosphere of nitrogen. After complete addition, the mixture was refluxed for 18 h, cooled to room temperature and concentrated in vacuo to yield the title product as a red oil. TLC: Rf=0.86, CH2Cl2. (1 H)-NMR (CDCl3) consistent with structure.

Workup

  1. additionAfter complete addition
  2. temperaturethe mixture was refluxed for 18 h
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-cb1e5219d978408ab5d8bd4e0f565cfa
Source dataset
uspto-grants-1998_07
Patent number
US05783701

Reaction notes

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