Hydrochloric Acid → HCID 19067876, compound

Participants

Reaction Conditions

Reaction Steps

2 Grams of 5,7-diallyl-3,4-dihydro-1-(ethoxy-carbonylmethyl)-6-hydroxy-2(1H)-quinolinone obtained in Example 57 was dissolved in 100 ml of 1N-sodium hydroxide aqueous solution, and the solution was stirred at 60° C. for 4 hours. Under ice-cooling condition, the reaction mixture was acidified with hydrochloric acid, the crystals thus precipitated were collected by filtration, washed with water and dried. There was obtained 0.8 g (53%) of 1-(carboxymethyl)-5,7-diallyl-3,4-dihydro-6-hydroxy-2(1H)-quinolinone.

Provenance & Evidence