Hydrochloric Acid → HCID 19067876, compound

HRID 1957546Notes

Reaction equation

HRID 1957546 reaction equation
[CH2:1]([C:4]1[C:13]([OH:14])=[C:12]([CH2:15][CH:16]=[CH2:17])[CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][C:8](=[O:24])[N:9]2[CH2:18][C:19]([O:21]CC)=[O:20])[CH:2]=[CH2:3].Cl>[OH-].[Na+]>[C:19]([CH2:18][N:9]1[C:10]2[C:5](=[C:4]([CH2:1][CH:2]=[CH2:3])[C:13]([OH:14])=[C:12]([CH2:15][CH:16]=[CH2:17])[CH:11]=2)[CH2:6][CH2:7][C:8]1=[O:24])([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19068021HCID 19068021, compound

Product 1

HCID 19067876HCID 19067876, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
60 °C

Procedure

2 Grams of 5,7-diallyl-3,4-dihydro-1-(ethoxy-carbonylmethyl)-6-hydroxy-2(1H)-quinolinone obtained in Example 57 was dissolved in 100 ml of 1N-sodium hydroxide aqueous solution, and the solution was stirred at 60° C. for 4 hours. Under ice-cooling condition, the reaction mixture was acidified with hydrochloric acid, the crystals thus precipitated were collected by filtration, washed with water and dried. There was obtained 0.8 g (53%) of 1-(carboxymethyl)-5,7-diallyl-3,4-dihydro-6-hydroxy-2(1H)-quinolinone.

Workup

  1. temperatureUnder ice-cooling condition
  2. customthe crystals thus precipitated
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-f759ac6815bf4b5ab11a45621926e602
Source dataset
uspto-grants-1998_07
Patent number
US05786367

Reaction notes

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