Hydrochloric Acid → HCID 178508892, compound

HRID 1957571Notes

Reaction equation

HRID 1957571 reaction equation
C([O:3][C:4](=[O:35])[CH2:5][NH:6][S:7]([C:10]1[S:11][C:12]([CH2:15][CH2:16][CH:17]2[CH2:34][NH:33][C:20]3[N:21]=[C:22]([NH:26]C(=O)C(C)(C)C)[N:23]=[C:24]([OH:25])[C:19]=3[CH2:18]2)=[CH:13][CH:14]=1)(=[O:9])=[O:8])C.Cl>[OH-].[Na+]>[NH2:26][C:22]1[N:23]=[C:24]([OH:25])[C:19]2[CH2:18][CH:17]([CH2:16][CH2:15][C:12]3[S:11][C:10]([S:7]([NH:6][CH2:5][C:4]([OH:35])=[O:3])(=[O:8])=[O:9])=[CH:14][CH:13]=3)[CH2:34][NH:33][C:20]=2[N:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178472926HCID 178472926, compound

Product 1

HCID 178508892HCID 178508892, compoundYield 109.2%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 33 mg (0.062 mmol) of N-{5-[2-(2-pivaloylamino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)-ethyl]thien-2-ylsulfonyl}glycine ethyl ester in 3.0 mL of 1.0N sodium hydroxide was stirred at room temperature for 24 hours. The reaction mixture was then acidified with 1.0N hydrochloric acid and the white precipitate was collected by filtration to give 28 mg of N-{5-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)-ethyl]thien-2-ylsulfonyl}glycine.

Workup

  1. filtrationthe white precipitate was collected by filtration

Sources & evidence

ORD record
ord-a94fbbaa178f4f23b6297561dfebce45
Source dataset
uspto-grants-1998_07
Patent number
US05786358

Reaction notes

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