Sodium Hydroxide → HCID 15896175, compound

HRID 1957783Notes

Reaction equation

HRID 1957783 reaction equation
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:9]2[C:10](=[O:32])[N:11]([CH2:17][C:18]3[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([C:28]([F:31])([F:30])[F:29])[CH:19]=3)[CH2:12][CH2:13][O:14][C:15]=2[N:16]=1)(=O)C.[OH-].[Na+]>C(O)C>[F:31][C:28]([F:29])([F:30])[C:20]1[CH:19]=[C:18]([CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=1)[CH2:17][N:11]1[C:10](=[O:32])[C:9]2[C:8]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[CH:7][C:6]([CH2:5][OH:4])=[N:16][C:15]=2[O:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15896174HCID 15896174, compound

Product 1

HCID 15896175HCID 15896175, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 8-acetoxymethyl-4-[3,5-bis(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-5-oxo-6-phenylpyrido[3,2-f][1,4]oxazepine (Example 37) (4,51 g), ethanol (50 ml), and 4N-NaOH (50 ml) was stirred for 1.5 hours at room temperature. After evaporation of the solvent, water was added to the residue. The pH of the mixture was adjusted to ca.8 using dilute hydrochloric acid, and extracted with ethyl acetate. The extract was washed with water, dried and evaporated to give the entitled compound as colorless crystals (4.10 g).

Workup

  1. customAfter evaporation of the solvent, water
  2. additionwas added to the residue
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with water
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-2b7c6a7eb8144690a41becc594530647
Source dataset
uspto-grants-1998_07
Patent number
US05786352

Reaction notes

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