反应详情

A suspension of 1-methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene (520 mg; 2.170 mmol) and 50 mg of Pd/C 10% in methanol (50 ml) was hydrogenated (1 bar) overnight. The reaction mixture was filtered on a celite pad and the obtained solution concentrated in vacuo. The crude was washed with dichloromethane in order to filter salts, coming from the previous reaction. 100 mg (0.395 mmol; 18% yield) were obtained.

1. custom(1 bar) overnight
2. filtrationThe reaction mixture was filtered on a celite pad
3. concentrationthe obtained solution concentrated in vacuo
4. washThe crude was washed with dichloromethane in order
5. filtrationto filter salts
6. customcoming from the previous reaction
7. custom100 mg (0.395 mmol; 18% yield) were obtained