1-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene → 3-(Methylsulfonyl)methyl-5-trifluoromethyl-aniline

Participants

Reaction Steps

A suspension of 1-methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene (520 mg; 2.170 mmol) and 50 mg of Pd/C 10% in methanol (50 ml) was hydrogenated (1 bar) overnight. The reaction mixture was filtered on a celite pad and the obtained solution concentrated in vacuo. The crude was washed with dichloromethane in order to filter salts, coming from the previous reaction. 100 mg (0.395 mmol; 18% yield) were obtained.

Provenance & Evidence