Hydrazine hydrate (1:1) → HCID 86640953, compound

HRID 1957972Notes

Reaction equation

HRID 1957972 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:10]([C:18](=O)[CH2:19][CH2:20][CH:21]2[CH2:23][CH2:22]2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].O.[NH2:27][NH2:28]>C(O)C>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:10]([C:18]2[CH:19]=[C:20]([CH:21]3[CH2:23][CH2:22]3)[NH:28][N:27]=2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68716960HCID 68716960, compound

Product 1

HCID 86640953HCID 86640953, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

[3-(3-Cyclopropyl-propionyl)-5-methanesulfonyl-phenyl]-carbamic acid tert-butyl ester (250 mg; 0.688 mmol) was diluted in 5 ml of ethanol and hydrazine hydrate (0.186 ml; 3.439 mmol) was added. The reaction mixture was stirred at room temperature for 1 h. Then, it was concentrated under vacuum. 200 mg (0.53 mmol; 77% yield) of [3-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(methylsulfonyl)-phenyl]-carbamic acid tert butyl ester were obtained.

Workup

  1. concentrationThen, it was concentrated under vacuum

Sources & evidence

ORD record
ord-a720ab753612410dbcbf2efdeed40fb3
Source dataset
uspto-grants-2013_04
Patent number
US08410100B2

Reaction notes

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