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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957973Generated: November 1, 2026

HCID 86640953, compound → HCID 59286113, compound

https://huagongshe.com/reaction/1957973

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 86640953HCID 86640953—
SolventHydrochloric AcidHCID 313—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 59286113HCID 5928611396.4%

Reaction Steps

[3-(5-Cyclopropyl-1H-pyrazol-3-yl)-5-(methylsulfonyl)-phenyl]-carbamic acid tert butyl ester (250 mg; 0.662 mmol) was suspended in 0.5 ml of 4 M HCl solution in 1,4-dioxane. The reaction mixture was stirred at room temperature for 1 h then it was concentrated in vacuo. 200 mg (0.638 mmol; 96% yield) of the desired aniline were obtained as hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08410100B2
Source datasetuspto-grants-2013_04
ORD IDord-cc1873b7cc224f1dac8dccca8706c8b3
Source noteuspto-grants-2013_04