HCID 86640953, compound → HCID 59286113, compound

HRID 1957973Notes

Reaction equation

HRID 1957973 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:10]([C:18]2[CH:22]=[C:21]([CH:23]3[CH2:25][CH2:24]3)[NH:20][N:19]=2)[CH:9]=1)(C)(C)C>Cl.O1CCOCC1>[CH:23]1([C:21]2[NH:20][N:19]=[C:18]([C:10]3[CH:9]=[C:8]([CH:13]=[C:12]([S:14]([CH3:17])(=[O:15])=[O:16])[CH:11]=3)[NH2:7])[CH:22]=2)[CH2:25][CH2:24]1

Participants

4

Reactant 1

HCID 86640953HCID 86640953, compound

Product 1

HCID 59286113HCID 59286113, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolvent2×HCID 312751,4-DioxaneSolvent

Procedure

[3-(5-Cyclopropyl-1H-pyrazol-3-yl)-5-(methylsulfonyl)-phenyl]-carbamic acid tert butyl ester (250 mg; 0.662 mmol) was suspended in 0.5 ml of 4 M HCl solution in 1,4-dioxane. The reaction mixture was stirred at room temperature for 1 h then it was concentrated in vacuo. 200 mg (0.638 mmol; 96% yield) of the desired aniline were obtained as hydrochloride.

Workup

  1. concentrationit was concentrated in vacuo

Sources & evidence

ORD record
ord-cc1873b7cc224f1dac8dccca8706c8b3
Source dataset
uspto-grants-2013_04
Patent number
US08410100B2

Reaction notes

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