1-Ethanesulfonyl-3-nitro-benzene → 3-(Ethanesulfonyl)aniline

HRID 1957974Notes

Reaction equation

HRID 1957974 reaction equation
[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)(=[O:5])=[O:4])[CH3:2].[H][H]>CO.[Ni]>[CH2:1]([S:3]([C:6]1[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=1)[NH2:12])(=[O:5])=[O:4])[CH3:2]

Participants

5

Reactant 2

HCID 127445851-Ethanesulfonyl-3-nitro-benzeneHCID 178418361HCID 178418361, compound

Product 1

HCID 127445953-(Ethanesulfonyl)aniline

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

1-(Ethylsulfonyl)-3-nitro-benzene (1.9 g; 9 mmol) was dissolved in 80 mL of methanol then 1 g of Raney-Nickel is added and the mixture treated with hydrogen gas. The reaction mixture was subsequently filtered and concentrated to yield 1.5 g (8.1 mmol; yield=93%) of an yellow oil.

Workup

  1. filtrationThe reaction mixture was subsequently filtered
  2. concentrationconcentrated
  3. customto yield 1.5 g (8.1 mmol; yield=93%) of an yellow oil

Sources & evidence

ORD record
ord-42afc673a9f24bb9acaa16317ba32abb
Source dataset
uspto-grants-2013_04
Patent number
US08410100B2

Reaction notes

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