HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate | HCID 6544479 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 59286178 | HCID 59286178 | — |
Reaction Steps
N-(Tert-butoxycarbonyl)-(R)-3-pyrrolidinol (5 g; 26.70 mmol) was diluted in 15 ml of methanol and 5 ml of HCl 37% were added. The reaction mixture was stirred at room temperature overnight, then it was concentrated in vacuo. 2.1 g (17.07 mmol; 63%) of the desired product were obtained as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410100B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d3cd3294f8654a0db4597ebeb4c723d6 |
| Source note | uspto-grants-2013_04 |