Hydrochloric Acid → Hydrochloric Acid

HRID 1957983Notes

Reaction equation

HRID 1957983 reaction equation
C(O[C:6]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)=O)(C)(C)C.[ClH:14]>CO>[CH:6]1([N:8]2[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]2)[CH2:12][CH2:11][CH2:10][CH2:9]1.[ClH:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 6544479tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate

Product 2

HCID 313Hydrochloric AcidHCID 59286178HCID 59286178, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(Tert-butoxycarbonyl)-(R)-3-pyrrolidinol (5 g; 26.70 mmol) was diluted in 15 ml of methanol and 5 ml of HCl 37% were added. The reaction mixture was stirred at room temperature overnight, then it was concentrated in vacuo. 2.1 g (17.07 mmol; 63%) of the desired product were obtained as hydrochloride.

Workup

  1. concentrationit was concentrated in vacuo

Sources & evidence

ORD record
ord-d3cd3294f8654a0db4597ebeb4c723d6
Source dataset
uspto-grants-2013_04
Patent number
US08410100B2

Reaction notes

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