反应详情

A suspension of [(2-chloro-5-nitro-pyrimidin-4-yl)-isopropyl-amino]-acetic acid ethyl ester (40 g; 0.132 mol), Pt/C5% (2 g) and vanadylacetylacetonate (2 g; 0.754 mmol) in THF (50 ml) was treated with hydrogen (5 bar) overnight. The reaction mixture was warmed (in order to solubilize the precipitate formed) and filtered on a celite pad, then concentrated in vacuo. The crude was diluted in ethyl acetate and the organic phase was washed with NaOH 10% solution, dried with MgSO4 and concentrated in vacuo. 28 g (0.115 mol; 87% yield) of solid material were obtained.

1. temperatureThe reaction mixture was warmed (in order
2. customformed) and
3. filtrationfiltered on a celite pad
4. concentrationconcentrated in vacuo
5. additionThe crude was diluted in ethyl acetate
6. washthe organic phase was washed with NaOH 10% solution
7. dry with materialdried with MgSO4
8. concentrationconcentrated in vacuo
9. custom28 g (0.115 mol; 87% yield) of solid material were obtained