Methyl 3-amino-5-(methylsulfonyl)benzoate → 3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-methanesulfonyl-benzoic acid

HRID 1957990Notes

Reaction equation

HRID 1957990 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][N:5]([CH:14]([CH3:16])[CH3:15])[C:4]=2[N:3]=1.C[O:18][C:19](=[O:31])[C:20]1[CH:25]=[C:24]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=[C:22]([NH2:30])[CH:21]=1>>[CH:14]([N:5]1[C:4]2[N:3]=[C:2]([NH:30][C:22]3[CH:21]=[C:20]([CH:25]=[C:24]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=3)[C:19]([OH:31])=[O:18])[N:11]=[CH:10][C:9]=2[N:8]([CH3:12])[C:7](=[O:13])[CH2:6]1)([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 18945412Methyl 3-amino-5-(methylsulfonyl)benzoateHCID 584059002-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one

Product 1

HCID 684241833-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-methanesulfonyl-benzoic acid

Procedure

Starting from 2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one (4.8 g; 0.05 mmol) and 3-amino-5-(methylsulfonyl)-benzoic acid methyl ester (5.5 g; 0.024 mmol), 6.4 g (15.27 mmol; 77% yield) of white powder were obtained.

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-4231b07ab4254caca5eb758be1ddfa03
Source dataset
uspto-grants-2013_04
Patent number
US08410100B2

Reaction notes

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