HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-amino-5-(methylsulfonyl)benzoate → 3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-methanesulfonyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-amino-5-(methylsulfonyl)benzoate | HCID 18945412 | — |
| Reactant | 2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one | HCID 58405900 | — |
| Product | 3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-methanesulfonyl-benzoic acid | HCID 68424183 | — |
Reaction Steps
Starting from 2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one (4.8 g; 0.05 mmol) and 3-amino-5-(methylsulfonyl)-benzoic acid methyl ester (5.5 g; 0.024 mmol), 6.4 g (15.27 mmol; 77% yield) of white powder were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410100B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4231b07ab4254caca5eb758be1ddfa03 |
| Source note | uspto-grants-2013_04 |