2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one → 3-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-nitro-benzenesulfonamide

HRID 1957992Notes

Reaction equation

HRID 1957992 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][N:5]([CH:14]([CH3:16])[CH3:15])[C:4]=2[N:3]=1.[NH2:17][C:18]1[CH:19]=[C:20]([S:27]([NH2:30])(=[O:29])=[O:28])[CH:21]=[C:22]([N+:24]([O-:26])=[O:25])[CH:23]=1>>[CH:14]([N:5]1[C:4]2[N:3]=[C:2]([NH:17][C:18]3[CH:19]=[C:20]([S:27]([NH2:30])(=[O:29])=[O:28])[CH:21]=[C:22]([N+:24]([O-:26])=[O:25])[CH:23]=3)[N:11]=[CH:10][C:9]=2[N:8]([CH3:12])[C:7](=[O:13])[CH2:6]1)([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 584059002-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-oneHCID 592861913-Amino-5-nitrobenzenesulfonamide

Product 1

HCID 684243023-(8-Isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-5-nitro-benzenesulfonamideYield 232.1%

Procedure

Starting from 2-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one (3.15 g; 4.502 mmol) and 3-amino-5-nitro-benzenesulfonamide (3.49 g; 14.502 mmol), 4.4 g (10.45 mmol; 72% yield) of the desired nitro-product were obtained as a powder.

Sources & evidence

ORD record
ord-41b7d4a2f7d24a2ca5bec8667845891f
Source dataset
uspto-grants-2013_04
Patent number
US08410100B2

Reaction notes

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