Ethanol, 2-[(3-aminophenyl)sulfonyl]- → HCID 59286160, compound

HRID 1957995Notes

Reaction equation

HRID 1957995 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][N:5]([CH:14]([CH3:16])[CH3:15])[C:4]=2[N:3]=1.[NH2:17][C:18]1[CH:19]=[C:20]([S:24]([CH2:27][CH2:28][OH:29])(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1>ClCCl>[OH:29][CH2:28][CH2:27][S:24]([C:20]1[CH:19]=[C:18]([NH:17][C:2]2[N:11]=[CH:10][C:9]3[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][N:5]([CH:14]([CH3:16])[CH3:15])[C:4]=3[N:3]=2)[CH:23]=[CH:22][CH:21]=1)(=[O:25])=[O:26]

Participants

4

Reactant 2

HCID 78905Ethanol, 2-[(3-aminophenyl)sulfonyl]-HCID 584059002-chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one

Product 1

HCID 59286160HCID 59286160, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Chloro-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one (150 mg; 0.623 mmol) and 2-(3-Amino-phenylsulfonyl)-ethanol (120 mg; 0.600 mmol) were heated to 160° C. for 30 minutes. The reaction mixture was then suspended in dichloromethane and ethyl acetate then filtrated to yield 215 mg (0.530 mmol; 85% yield) as yellow solid.

Workup

  1. filtrationethyl acetate then filtrated
  2. customto yield 215 mg (0.530 mmol; 85% yield) as yellow solid

Sources & evidence

ORD record
ord-e6f8360d980f4d35beeed0dc9faad072
Source dataset
uspto-grants-2013_04
Patent number
US08410100B2

Reaction notes

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