Formic Acid → HCID 178503371, compound

HRID 1958020Notes

Reaction equation

HRID 1958020 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([S:10][CH3:11])[S:5][C:6]=1[C:7]([NH2:9])=[O:8].[CH:12](O)=O>O>[CH3:11][S:10][C:4]1[S:5][C:6]2[C:7](=[O:8])[N:9]=[CH:12][NH:1][C:2]=2[N:3]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 3256534-Amino-2-(methylsulfanyl)-1,3-thiazole-5-carboxamide

Product 1

HCID 178503371HCID 178503371, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-amino-2-(methylthio)thiazole-5-carboxamide (3.37 g, 17.8 mmol) in formic acid (10 mL) was stirred at reflux for 12 hours. After cooled to ambient temperature, the reaction mixture was diluted with water (30 mL) and the precipitate was collected by filtration. The resulting solid was further washed with water and dried in vacuo. The product was obtained as a yellow solid (2.978 g, 84%). 1H NMR (300 MHz, d6-DMSO) δ 12.83 (br, 1H), 8.26 (s, 1H), 2.80 (s, 3H); LC-MS: 200 (MH+).

Workup

  1. temperatureat reflux for 12 hours
  2. filtrationthe precipitate was collected by filtration
  3. washThe resulting solid was further washed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-7cbd722bf6d74a1491d60d7833089df7
Source dataset
uspto-grants-2013_04
Patent number
US08410095B2

Reaction notes

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