Formic Acid → HCID 178503371, compound

Participants

Reaction Steps

A mixture of 4-amino-2-(methylthio)thiazole-5-carboxamide (3.37 g, 17.8 mmol) in formic acid (10 mL) was stirred at reflux for 12 hours. After cooled to ambient temperature, the reaction mixture was diluted with water (30 mL) and the precipitate was collected by filtration. The resulting solid was further washed with water and dried in vacuo. The product was obtained as a yellow solid (2.978 g, 84%). 1H NMR (300 MHz, d6-DMSO) δ 12.83 (br, 1H), 8.26 (s, 1H), 2.80 (s, 3H); LC-MS: 200 (MH+).

Provenance & Evidence