2-Hydroxyisonicotinic Acid → N-[5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-1,2-dihydro-2-oxo-4-pyridinecarboxylic acid amide

HRID 1958133Notes

Reaction equation

HRID 1958133 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[O:21]=[C:22]1[CH:27]=[C:26]([C:28](O)=[O:29])[CH:25]=[CH:24][NH:23]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:28]([C:26]3[CH:25]=[CH:24][NH:23][C:22](=[O:21])[CH:27]=3)=[O:29])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2807562-Hydroxyisonicotinic AcidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56961659N-[5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-1,2-dihydro-2-oxo-4-pyridinecarboxylic acid amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2, 2-trifluoro-ethoxy)-pyridin-3-ylamine and 1,2-dihydro-2-oxo-4-pyridinecarboxylic acid, as starting materials, MS (LC/MS): 424.0 (M+H).

Sources & evidence

ORD record
ord-de6a1fbe28c34cff90d5a59db03109e7
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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