HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate | HCID 86619571 | — |
| Product | 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester | HCID 67281036 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 48a, using 5-bromo-6-(4-chlorophenyl)-2-pyrazinecarboxylic acid methyl ester (CAN 960247-79-4) and 2,2,2-trifluoroethanol as starting materials; MS (EI) 347.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410107B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f17bf34db2064db7b688a83c25194a73 |
| Source note | uspto-grants-2013_04 |