2,2,2-Trifluoroethanol → 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester

HRID 1958156Notes

Reaction equation

HRID 1958156 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8](Br)=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:6]=1)=[O:4].[F:19][C:20]([F:24])([F:23])[CH2:21][OH:22]>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([O:22][CH2:21][C:20]([F:24])([F:23])[F:19])=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 86619571Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate

Product 1

HCID 672810366-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester

Procedure

The title compound was synthesized in analogy to Example 48a, using 5-bromo-6-(4-chlorophenyl)-2-pyrazinecarboxylic acid methyl ester (CAN 960247-79-4) and 2,2,2-trifluoroethanol as starting materials; MS (EI) 347.1 (M+H)+.

Sources & evidence

ORD record
ord-f17bf34db2064db7b688a83c25194a73
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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