2-Hydroxyisonicotinic Acid → HCID 178422836, compound

HRID 1958167Notes

Reaction equation

HRID 1958167 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][C:3]=1[CH3:21].[O:22]=[C:23]1[CH:28]=[C:27]([C:29](O)=[O:30])[CH:26]=[CH:25][NH:24]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:29](=[O:30])[C:27]3[CH:26]=[CH:25][N:24]=[C:23]([OH:22])[CH:28]=3)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:4][C:3]=1[CH3:21]

Participants

3

Reactant 2

HCID 2807562-Hydroxyisonicotinic AcidHCID 672811395-(4-Chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 178422836HCID 178422836, compound

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-Chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example 57 a) and 1,2-dihydro-2-oxo-4-pyridinecarboxylic acid (CAN 22282-72-0) as starting materials; LC-MS (UV peak area/ESI) 100%, 436.0689 (M−H)−.

Sources & evidence

ORD record
ord-4f638d787c6642d49d6c982edd48ee20
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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