5-Cyanopyridine-3-carboxylic acid → N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-cyanonicotinamide
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][C:3]=1[CH3:21].[C:22]([C:24]1[CH:25]=[C:26]([C:30](O)=[O:31])[CH:27]=[N:28][CH:29]=1)#[N:23]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:30](=[O:31])[C:26]3[CH:25]=[C:24]([C:22]#[N:23])[CH:29]=[N:28][CH:27]=3)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:4][C:3]=1[CH3:21]Participants
3
Procedure
The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example 57 a) and 5-cyano-3-pyridinecarboxylic acid, (CAN 887579-62-6) as starting materials; LC-MS (UV peak area/ESI) 98.7%, 445.0693 (M−H)−.
Sources & evidence
- ORD record
- ord-69a911043f4d45609d19a77f9785ef0e
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08410107B2
Reaction notes
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