HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyanopyridine-3-carboxylic acid → N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-cyanonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyanopyridine-3-carboxylic acid | HCID 22174782 | — |
| Reactant | 5-(4-Chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine | HCID 67281139 | — |
| Product | N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-cyanonicotinamide | HCID 56962108 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example 57 a) and 5-cyano-3-pyridinecarboxylic acid, (CAN 887579-62-6) as starting materials; LC-MS (UV peak area/ESI) 98.7%, 445.0693 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410107B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-69a911043f4d45609d19a77f9785ef0e |
| Source note | uspto-grants-2013_04 |