3-Pyridinecarbonyl chloride, hydrochloride (1:1) → N-(5-(4-chlorophenyl)-6-cyclobutoxypyridin-3-yl)nicotinamide

HRID 1958196Notes

Reaction equation

HRID 1958196 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:19])[CH:11]=[N:12][C:13]=2[O:14][CH:15]2[CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1.Cl.[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH:19][C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=3)[CH:11]=[N:12][C:13]=2[O:14][CH:15]2[CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 672811445-(4-Chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine

Product 1

HCID 56962003N-(5-(4-chlorophenyl)-6-cyclobutoxypyridin-3-yl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 48e, using 5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine (example 78 d) and nicotinoyl chloride hydrochloride as starting materials; MS (EI) 380.2(M+H)+.

Sources & evidence

ORD record
ord-da18aa165d044f9395c5e527bd7bc5ed
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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