4-Chloro-3-fluorophenylboronic Acid → 5-(4-Chloro-3-fluoro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

HRID 1958198노트

반응식

HRID 1958198 반응식
Br[C:2]1[CH:3]=[C:4]([NH2:14])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[Cl:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][C:17]=1[F:25]>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[CH:3]=[C:4]([NH2:14])[CH:5]=[N:6][C:7]=2[O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[CH:18][C:17]=1[F:25]

참가 물질

3

반응물 2

HCID 27786564-Chloro-3-fluorophenylboronic AcidHCID 672810445-Bromo-6-(2,2,2-trifluoroethoxy)-pyridin-3-ylamine

생성물 1

HCID 672803905-(4-Chloro-3-fluoro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

실험 절차

The title compound was synthesized in analogy to Example E, using 5-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example C) and B-(4-chloro-3-fluorophenyl)-boronic acid (CAN 137504-86-0) as starting materials; MS (EI) 379.3 (M+OAc)+.

출처 및 근거

ORD 기록
ord-ecb39ddb23bb4a0397a62b93e9e6afe3
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410107B2

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