5-methyl-1,3-oxazole-4-carboxylic Acid → 5-Methyl-oxazole-4-carboxylic acid[5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-yl]-amide

HRID 1958200Notes

Reaction equation

HRID 1958200 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:19])[CH:11]=[N:12][C:13]=2[O:14][CH:15]2[CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1.[CH3:20][C:21]1[O:25][CH:24]=[N:23][C:22]=1[C:26](O)=[O:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH:19][C:26]([C:22]3[N:23]=[CH:24][O:25][C:21]=3[CH3:20])=[O:27])[CH:11]=[N:12][C:13]=2[O:14][CH:15]2[CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 113554845-methyl-1,3-oxazole-4-carboxylic AcidHCID 672811445-(4-Chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine

Product 1

HCID 569620535-Methyl-oxazole-4-carboxylic acid[5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-yl]-amide

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine (example 78 d) and 5-methyl-4-oxazolecarboxylic acid (CAN 103879-58-9) as starting materials; LC-MS (UV peak area/ESI) 100%, 384.1102 (M+H)+.

Sources & evidence

ORD record
ord-2757cdf63a0c4abe9f58f3ba5d6f8c72
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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