5-Methylnicotinic acid → N-[5-(4-Chloro-phenyl)-6-cyclobutoxy-pyridin-3-yl]-5-methyl-nicotinamide

HRID 1958201Notes

Reaction equation

HRID 1958201 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:19])[CH:11]=[N:12][C:13]=2[O:14][CH:15]2[CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1.[CH3:20][C:21]1[CH:22]=[C:23]([C:27](O)=[O:28])[CH:24]=[N:25][CH:26]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH:19][C:27](=[O:28])[C:23]3[CH:22]=[C:21]([CH3:20])[CH:26]=[N:25][CH:24]=3)[CH:11]=[N:12][C:13]=2[O:14][CH:15]2[CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2562085-Methylnicotinic acidHCID 672811445-(4-Chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine

Product 1

HCID 56962054N-[5-(4-Chloro-phenyl)-6-cyclobutoxy-pyridin-3-yl]-5-methyl-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine (example 78 d) and 5-methyl-3-pyridinecarboxylic acid (CAN 40473-04-9) as starting materials; MS (EI) 394.1 (M+H)+.

Sources & evidence

ORD record
ord-99e675c945744b118f2f5a55e7e8c3c9
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

Loading…