HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1958300Generated: November 1, 2026
4-Cyanophenylhydrazine Hydrochloride → 6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-N,N,5-trimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide
https://huagongshe.com/reaction/1958300
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Cyanophenylhydrazine Hydrochloride | HCID 16212962 | — |
| Reactant | 6-(3,3-Diethoxyprop-1-ynyl)-N,N,5-trimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide | HCID 66738718 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-N,N,5-trimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide | HCID 24890313 | 29.5% |
Reaction Steps
6-(3,3-Diethoxyprop-1-ynyl)-N,N,5-trimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide (0.028 g, 0.062 mmol) was dissolved in DMF (1 ml) in a microwave vial. 4-Cyanophenylhydrazine hydrochloride (0.013 g, 0.074 mmol) was added. The vial was sealed and heated with stirring to 120° C. for 5 minutes. The crude mixture was purified on preparative HPLC to give 9 mg (29%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08410114B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-8f4fe226f98444298edfbccc6b42ec9e |
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| Source note | uspto-grants-2013_04 |
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