Hydrochloric Acid → HCID 178522280, compound

HRID 1958317Notes

Reaction equation

HRID 1958317 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[NH:8][N:9]=[N:10][C:11]=1[C:12](=[O:29])[NH:13][C:14]1[CH:19]=[CH:18][N:17]2[CH:20]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:22]=[C:16]2[N:15]=1)=[O:6].Cl>CO.C1COCC1>[C:23]1([C:21]2[N:22]=[C:16]3[N:15]=[C:14]([NH:13][C:12]([C:11]4[N:10]=[N:9][NH:8][C:7]=4[C:5]([OH:6])=[O:4])=[O:29])[CH:19]=[CH:18][N:17]3[CH:20]=2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178499157HCID 178499157, compound

Product 1

HCID 178522280HCID 178522280, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

NaOH (3N, 1.47 ml) was added to a solution of 5-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-3H-[1,2,3]triazole-4-carboxylic acid methyl ester (example 26, 800 mg, 2.2 mmol) in methanol/THF=1:1 (16 ml), and the mixture was stirred for 6 h at RT. The mixture was acidified (pH=3) with HCl (2N), the suspension was stirred for 15 min, and filtered. The precipitated title compound (590 mg, 77%) was dried under vacuum, and used in the next step without further purification.

Workup

  1. stirringthe suspension was stirred for 15 min
  2. filtrationfiltered
  3. customThe precipitated title compound (590 mg, 77%)
  4. customwas dried under vacuum
  5. customused in the next step without further purification

Sources & evidence

ORD record
ord-cae3bbfed8874453a22ad7851a5f8c6c
Source dataset
uspto-grants-2013_04
Patent number
US08410117B2

Reaction notes

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