反应详情

NaOH (3N, 6.9 ml) was added to a solution of 1-methyl-5-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester (2.70 g, 6.9 mmol) in THF/ethanol=1:1 (40 ml), an the mixture was stirred at RT overnight. Water (10 ml) and HCl (conc., approx. 3 ml) were added to the cooled (0° C.) mixture, until the mixture had a pH of 3. The suspension was stirred for 15 min, and filtered. The precipitate was washed with a small amount of water, and dried under vacuum. The thus obtained product (910 mg, 36%) was used in the next step without further purification. MS (m/e)=361.3 [M−H+].

1. temperaturecooled (0° C.) mixture
2. stirringThe suspension was stirred for 15 min
3. filtrationfiltered
4. washThe precipitate was washed with a small amount of water
5. customdried under vacuum
6. customThe thus obtained product (910 mg, 36%) was used in the next step without further purification