HCID 58446794, compound → 4-(3-Fluoro-azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid {2-[3-(2-fluoro-ethoxy)-phenyl]imidazo[1,2-a]pyrimidin-7-yl}-amide

HRID 1958352Notes

Reaction equation

HRID 1958352 reaction equation
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:11]2[N:12]=[C:13]3[N:18]=[C:17]([NH2:19])[CH:16]=[CH:15][N:14]3[CH:20]=2)[CH:8]=[CH:9][CH:10]=1.[F:21][CH:22]1[CH2:25][N:24]([C:26]([C:28]2[CH:29]=[N:30][N:31]([CH3:36])[C:32]=2[C:33](O)=[O:34])=[O:27])[CH2:23]1>>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:11]2[N:12]=[C:13]3[N:18]=[C:17]([NH:19][C:33]([C:32]4[N:31]([CH3:36])[N:30]=[CH:29][C:28]=4[C:26]([N:24]4[CH2:23][CH:22]([F:21])[CH2:25]4)=[O:27])=[O:34])[CH:16]=[CH:15][N:14]3[CH:20]=2)[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 58446794HCID 58446794, compoundHCID 584467964-(3-fluoroazetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid

Product 1

HCID 534682434-(3-Fluoro-azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid {2-[3-(2-fluoro-ethoxy)-phenyl]imidazo[1,2-a]pyrimidin-7-yl}-amide

Procedure

The title compound was prepared in analogy to example 82 from 2-(3-(2-fluoroethoxy)phenyl)imidazo[1,2-a]pyrimidin-7-amine (120 mg) and 4-(3-fluoroazetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (100 mg, 440 μmol). Light brown solid (132 mg, 60%). MS (m/z)=482.2 [M+H+].

Sources & evidence

ORD record
ord-f9de7b8e908c4c24b70c012b128b88c0
Source dataset
uspto-grants-2013_04
Patent number
US08410117B2

Reaction notes

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