Hydrochloric Acid → Hydrochloric Acid

HRID 1958461Notes

Reaction equation

HRID 1958461 reaction equation
[N:1]1([C:6]2[CH:31]=[CH:30][C:9]([O:10][CH2:11][C:12]3[N:13]=[C:14]([CH:17]4[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]4)[S:15][CH:16]=3)=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1.[ClH:32]>CO.ClCCl.O1CCOCC1>[ClH:32].[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:10][CH2:11][C:12]3[N:13]=[C:14]([CH:17]4[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]4)[S:15][CH:16]=3)=[CH:30][CH:31]=2)[CH:5]=[N:4][N:3]=[N:2]1.[ClH:32]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 25024141tert-butyl 4-(4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)thiazol-2-yl)piperidine-1-carboxylate

Product 2

HCID 313Hydrochloric AcidHCID 67111747HCID 67111747, compound

Reagents, catalysts & solvents 2

HCID 312751,4-DioxaneSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

To a solution of tert-butyl 4-(4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)thiazol-2-yl)piperidine-1-carboxylate (0.60 g) in methanol/dichloromethane (1.0 mL/1.5 mL) was added 4N HCl in dioxane (1.7 mL) at 0° C., and then stirred at room temperature for 7 hours. After removal of solvents in vacuo, a crude desired compound HCl salt was obtained as an off-white solid.

Workup

  1. customAfter removal of solvents in vacuo

Sources & evidence

ORD record
ord-0501d731557445c39eadc8230dc63571
Source dataset
uspto-grants-2013_04
Patent number
US08410127B2

Reaction notes

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