HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → tert-Butyl 4-carbamoyl-4-[(3,3,3-trifluoropropyl)amino]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 3,3,3-Trifluoropropanal | HCID 68028 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | HCID 10562199 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl 4-carbamoyl-4-[(3,3,3-trifluoropropyl)amino]piperidine-1-carboxylate | HCID 86656052 | — |
Reaction Steps
10 g of tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate, 4.42 g of 3,3,3-trifluoropropionaldehyde, 17.61 g of sodium triacetoxyborohydride and 4.51 ml of acetic acid are added at AT to 250 ml of CH2Cl2 and then the mixture is stirred for 3 hours. Water is added and the expected compound is extracted with CH2Cl2 and the organic phase is washed with a saturated NaHCO3 solution and then with water. After drying the organic phase, filtering and evaporating to dryness, 13 g of the expected compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410137B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-cbc9ef0bec8d45d4beac548141775b9f |
| Source note | uspto-grants-2013_04 |