反应详情

10 g of tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate, 4.42 g of 3,3,3-trifluoropropionaldehyde, 17.61 g of sodium triacetoxyborohydride and 4.51 ml of acetic acid are added at AT to 250 ml of CH2Cl2 and then the mixture is stirred for 3 hours. Water is added and the expected compound is extracted with CH2Cl2 and the organic phase is washed with a saturated NaHCO3 solution and then with water. After drying the organic phase, filtering and evaporating to dryness, 13 g of the expected compound are obtained.

1. extractionthe expected compound is extracted with CH2Cl2
2. washthe organic phase is washed with a saturated NaHCO3 solution
3. customAfter drying the organic phase
4. filtrationfiltering
5. customevaporating to dryness, 13 g of the expected compound
6. customare obtained