Hydrochloric Acid → HCID 58367581, compound

HRID 1958690Notes

Reaction equation

HRID 1958690 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([C:14]([N:16]2[CH2:21][CH2:20][C:19]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)([C:22]([NH2:24])=[O:23])[CH2:18][CH2:17]2)=[O:15])=[CH:11][C:10]=1[C:31]1[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH2:39][CH2:40][O:41]C2CCCCO2)=[CH:33][CH:32]=1.Cl>CO>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([C:14]([N:16]2[CH2:17][CH2:18][C:19]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)([C:22]([NH2:24])=[O:23])[CH2:20][CH2:21]2)=[O:15])=[CH:11][C:10]=1[C:31]1[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH2:39][CH2:40][OH:41])=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67185456HCID 67185456, compound

Product 1

HCID 58367581HCID 58367581, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.6 g of the compound obtained in stage 16H) and 2 ml of 2N etheral hydrochloric acid are added to 15 ml of methanol. After 2 hours at AT, the expected compound is filtered off. 0.385 g of the expected compound is obtained.

Workup

  1. filtrationthe expected compound is filtered off

Sources & evidence

ORD record
ord-35c995258ca545f29854acd4ec491d37
Source dataset
uspto-grants-2013_04
Patent number
US08410137B2

Reaction notes

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