Hydrochloric Acid → HCID 67299425, compound

HRID 1958691Notes

Reaction equation

HRID 1958691 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([C:14]([N:16]2[CH2:21][CH2:20][C:19]([C:30]([NH2:32])=[O:31])([N:22]3[CH2:27][CH2:26][C:25]([F:29])([F:28])[CH2:24][CH2:23]3)[CH2:18][CH2:17]2)=[O:15])=[CH:11][C:10]=1[C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][CH2:42][O:43]C2CCCCO2)=[CH:35][CH:34]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([C:14]([N:16]2[CH2:21][CH2:20][C:19]([C:30]([NH2:32])=[O:31])([N:22]3[CH2:23][CH2:24][C:25]([F:28])([F:29])[CH2:26][CH2:27]3)[CH2:18][CH2:17]2)=[O:15])=[CH:11][C:10]=1[C:33]1[CH:34]=[CH:35][C:36]([O:39][CH2:40][CH2:41][CH2:42][OH:43])=[CH:37][CH:38]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67299516HCID 67299516, compound

Product 1

HCID 67299425HCID 67299425, compoundYield 208.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.63 g of the compound obtained in stage 17A) and 2 ml of 2N ethereal hydrochloric acid are added to 15 ml of methanol. After 1 hour at AT, concentrating to dryness and then crystallizing from AcOEt, 0.612 g of the expected compound is obtained.

Workup

  1. concentrationconcentrating to dryness
  2. customcrystallizing from AcOEt

Sources & evidence

ORD record
ord-2953b6b354fe4cc8891316da41b69f8f
Source dataset
uspto-grants-2013_04
Patent number
US08410137B2

Reaction notes

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