Hydrochloric Acid → HCID 86656053, compound

HRID 1958692Notes

Reaction equation

HRID 1958692 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([C:14]([N:16]2[CH2:21][CH2:20][C:19]([NH:25][CH2:26][CH2:27][C:28]([F:31])([F:30])[F:29])([C:22]([NH2:24])=[O:23])[CH2:18][CH2:17]2)=[O:15])=[CH:11][C:10]=1[C:32]1[CH:37]=[CH:36][C:35]([O:38][CH2:39][CH2:40][CH2:41][O:42]C2CCCCO2)=[CH:34][CH:33]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([C:14]([N:16]2[CH2:21][CH2:20][C:19]([NH:25][CH2:26][CH2:27][C:28]([F:31])([F:30])[F:29])([C:22]([NH2:24])=[O:23])[CH2:18][CH2:17]2)=[O:15])=[CH:11][C:10]=1[C:32]1[CH:33]=[CH:34][C:35]([O:38][CH2:39][CH2:40][CH2:41][OH:42])=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67184199HCID 67184199, compound

Product 1

HCID 86656053HCID 86656053, compoundYield 174.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.7 g of the compound obtained in stage 18A) and 3 ml of 2N ethereal hydrochloric acid are added to 15 ml of methanol. After 2 hours at AT, concentrating to dryness, taking up the residue in ether and then filtering, 0.57 g of the expected compound is obtained.

Workup

  1. concentrationconcentrating to dryness
  2. filtrationfiltering

Sources & evidence

ORD record
ord-f028d62e00b343c9b2796b04a15bd0f5
Source dataset
uspto-grants-2013_04
Patent number
US08410137B2

Reaction notes

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