HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Isoxazol-3-yl)thiophene-2-sulfonyl chloride → (R)-benzyl 4-(dimethylamino)-3-(5-(isoxazol-3-yl)thiophene-2-sulfonamido)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Isoxazol-3-yl)thiophene-2-sulfonyl chloride | HCID 2797180 | — |
| Reactant | (R)-benzyl 3-amino-4-(dimethylamino)butanoate | HCID 46223508 | — |
| Product | (R)-benzyl 4-(dimethylamino)-3-(5-(isoxazol-3-yl)thiophene-2-sulfonamido)butanoate | HCID 86641218 | 84% |
Reaction Steps
According to the method described in example S20a, (R)-benzyl 3-amino-4-(dimethylamino)butanoate (27 mg, 0.086 mmol) was reacted with 5-(isoxazol-3-yl)thiophene-2-sulfonyl chloride to yield the title compound as a white solid (38 mg, 84%). MS ESI 450.2 [M+H]+, calcd for [C20H23N3O5S2+H]+ 450.11
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410150B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d97f546337594cf8812b8f244406f68c |
| Source note | uspto-grants-2013_04 |